Soluble Extract from Moringa oleifera Leaves with a New Anticancer Activity

Apr 27, 2015

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Moringa oleifera has been regarded as a food substance since ancient times and has also been used as a treatment for many diseases. Recently, various therapeutic effects of M. oleifera such as antimicrobial, anticancer, anti-inflammatory, antidiabetic, and antioxidant effects have been investigated; however, most of these studies described only simple biological phenomena and their chemical compositions. Due to the increasing attention on natural products, such as those from plants, and the advantages of oral administration of anticancer drugs, soluble extracts from M. oleifera leaves (MOL) have been prepared and their potential as new anticancer drug candidates has been assessed in this study. Here, the soluble cold Distilled Water extract (4°C; concentration, 300 µg/mL) from MOL greatly induced apoptosis, inhibited tumor cell growth, and lowered the level of internal reactive oxygen species (ROS) in human lung cancer cells as well as other several types of cancer cells, suggesting that the treatment of cancer cells with MOL significantly reduced cancer cell proliferation and invasion. Moreover, over 90% of the genes tested were unexpectedly downregulated more than 2-fold, while just below 1% of the genes were upregulated more than 2-fold in MOL extract-treated cells, when compared with nontreated cells. Since severe dose-dependent rRNA degradation was observed, the abnormal downregulation of numerous genes was considered to be attributable to abnormal RNA formation caused by treatment with MOL extracts. Additionally, the MOL extract showed greater cytotoxicity for tumor cells than for normal cells, strongly suggesting that it could potentially be an ideal anticancer therapeutic candidate specific to cancer cells. These results suggest the potential therapeutic implications of the soluble extract from MOL in the treatment of various types of cancers. Full Article
Post by Matorwmasen

My name is Clement Matorwmasen. Together with my wife I have co-founded Green Gold Social Enterprise. Since childhood I have always been a social and environmental activist and I was a youth leader in many activist groups. As a child I grew up in difficult circumstances when my parents abandoned me and I grew up at the homes of different foreign missionaries. As a teenager I re-established the contact with my family members and my tribe and I learned I was high up in the royal family lineage. I now have very strong ties to my tribe and I want to make a difference in not only their lives, but that of all Ghanaians. When I reconnected with my family, I was already running several not-for-profit projects trying to improve the living conditions in several poor communities, like organising finances for a community boreholes to improve access to clean drinking water. I was doing this alongside my teaching job as an IT-specialist at a tertiary institution. In 2007 my boss and mentor introduced me to Moringa. I was intrigued and went to learn more about the plant and all its qualities and I saw it as a potential solution to combat malnutrition in our communities. This inspired me to set up my own NGO called Drive Aid Ghana and we started promoting the usage and cultivation of Moringa. I was happy that I could make a difference for some people, but scaling and sustaining our activities were highly problematic. Initially I was able to interest farmers in growing Moringa, but mostly they ended up cutting it down because they were not able to generate income from it. This was because there was no established local market. They also challenged me: ‘if Moringa is so useful and if you can earn so much money with it, then why don’t you do it yourself?’ These experiences made me think and slowly the idea of starting a social enterprise to promote Moringa as a cash crop started to develop. With the full support of my wife I handed over my IT-business to my brother and went full-time into developing our social enterprise Green Gold. We have been donated an abandoned state farm of 3000 ha by one of our communities, which we are currently developing into a Moringa plantation and processing factory. My quest is simply to make a difference in other people’s lives and to make the world a better place one smile at a time, Moringa is my pivot point for sustainable development

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